Researchers request samples by submitting an application to the biobank. This application gathers basic information about the study, such as the purpose of the study and how samples will be used. Researchers can also request medical data that the biobank has access to through donor's medical records. Any data that is shared with researchers is anonymized. 

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The biobank reviews each sample request application by considering three important questions:

1. Does the study answer important scientific questions?

2. Does the study pose any risk or harm to biobank donors?

3. Can the biobank reasonably fulfill the sample request?

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In additionally, a member of the biobank leadership team will also meet with the researcher and gather more information about the study. During this meeting, the researcher will be able to answer questions and/or address concerns that the biobank might have.

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If a researcher's sample request application is approved, they will complete a Material Transfer Agreement. This sets the terms and conditions for how a sample can be used and ensures that the researcher will only use the samples for the research project that they submitted an application for.

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After this agreement is signed, the researcher and the biobank will agree on a cost for the samples they have requested. The cost for the samples will depend on various factors, such as how many samples are being requested, the kinds of samples that are requested, and whether the researcher is affiliated with the Indiana University School of Medicine. The money that is paid to the biobank for samples is strictly used to cover the overall operating costs of the biobank.​​​​