Inside the Indiana Biobank
Giving donors an in-depth look at the biobank's commitment to transforming samples into responsible and impactful research
Publications
Upon completion of a study, researchers are encouraged to share any of their published findings with the biobank. Provided here is a partial list of these publications, separated based on topic area.
COVID-19
• Longitudinal SARS-CoV-2 seroconversion and functional heterogeneity in a pediatric dialysis unit. https://pubmed.ncbi.nlm.nih.gov/33509357/ • Placement on COVID-19 Units Does Not Increase Seroconversion Rate of Pediatric Graduate Medical Residents. https://pubmed.ncbi.nlm.nih.gov/33996685/ • Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19? https://pmc.ncbi.nlm.nih.gov/articles/PMC8542928/ • T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults. https://pubmed.ncbi.nlm.nih.gov/36633825/ • Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors. https://pubs.acs.org/doi/10.1021/acs.analchem.0c05300 • Team Science to maximize rapid collection and analyses of biosamples from patients with Covid-19. https://pmc.ncbi.nlm.nih.gov/articles/PMC8827782/ • Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19. https://pmc.ncbi.nlm.nih.gov/articles/PMC8083685/
Cardiovascular Health
• Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline-rich protein 1A. https://pubmed.ncbi.nlm.nih.gov/34403363/ • Evaluation of the Genetic Basis of Familial Aggregation of Pacemaker Implantation by a Large Next Generation Sequencing Panel. https://pubmed.ncbi.nlm.nih.gov/26636822/ • Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease. https://pubmed.ncbi.nlm.nih.gov/30463841/ • Comprehensive Next Generation Sequencing Assay for Identifying Pathogenic Variants Associated with Cardiovascular Diseases. https://www.jacc.org/doi/10.1016/S0735-1097%2817%2934318-8 • Molecular screening of familial hypercholesterolemia in Icelanders. https://pubmed.ncbi.nlm.nih.gov/32706999/ • Ondansetron blocks wild-type and p.F503L variant small-conductance Ca(2+)-activated K(+) channels. https://pubmed.ncbi.nlm.nih.gov/29677462/ • Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. https://www.nature.com/articles/ncomms13710
Cancer Detection and Prevention
• Sequential phosphoproteomics and N-glycoproteomics of plasma-derived extracellular vesicles. https://www.nature.com/articles/s41596-019-0260-5 • Polyphenol-mediated epigenetic reactivation of tumor suppressor gene SEMA3A in breast cancer cells. https://aacrjournals.org/cancerres/article/77/13_Supplement/4353/620000/Abstract-4353-Polyphenol-mediated-epigenetic • Cryopreservation Preserves Cell-Type Composition and Gene Expression Profiles in Bone Marrow Aspirates From Multiple Myeloma Patients. https://pubmed.ncbi.nlm.nih.gov/33968139/ • Analytical Pipeline for Discovery and Verification of Glycoproteins from Plasma-Derived Extracellular Vesicles as Breast Cancer Biomarkers. https://pubs.acs.org/doi/10.1021/acs.analchem.8b01090 • Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development. https://pubmed.ncbi.nlm.nih.gov/29927686/ • Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma. https://pubmed.ncbi.nlm.nih.gov/27025456/ • A novel liquid biopsy-based approach for highly specific cancer diagnostics: mitigating false responses in assaying patient plasma-derived circulating microRNAs through combined SERS and plasmon-enhanced fluorescence analyses. https://pubs.rsc.org/en/content/articlelanding/2020/an/d0an00538j • Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences. https://pubmed.ncbi.nlm.nih.gov/29545929/ • LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer. https://pubmed.ncbi.nlm.nih.gov/36914206/
Kidney and Liver Disease
• Alterations in Protein Translation and Carboxylic Acid Catabolic Processes in Diabetic Kidney Disease. https://pubmed.ncbi.nlm.nih.gov/35406730/ • Incidence and Importance of Calcium Deposition in Kidney Biopsy Specimens. https://pubmed.ncbi.nlm.nih.gov/35871513/ • The kidney protects against sepsis by producing systemic uromodulin. https://pubmed.ncbi.nlm.nih.gov/35759740/ • An atlas of healthy and injured cell states and niches in the human kidney. https://www.nature.com/articles/s41586-023-05769-3 • Novel HLA Class I Alleles Outside the Extended DR3 Haplotype Are Protective against Autoimmune Hepatitis. https://pubmed.ncbi.nlm.nih.gov/31211758/ • Germline Mutations in CIDEB and Protection against Liver Disease. https://www.nejm.org/doi/full/10.1056/NEJMoa2117872
Brain Health
• Associations between alcohol use disorder polygenic score and remission in participants from high‐risk families and the Indiana Biobank. https://pubmed.ncbi.nlm.nih.gov/38054532/ • Telomere Shortening in the Alzheimer's Disease Neuroimaging Initiative Cohort. https://pubmed.ncbi.nlm.nih.gov/31322561/ • Biological Hallmarks of Cancer in Alzheimer's Disease. https://pmc.ncbi.nlm.nih.gov/articles/PMC6728183/ • Large Scale Screening and Quantitative Analysis of Site-Specific N-Glycopeptides from Human Serum in Early Alzheimer's Disease Using LC-HCD-PRM-MS. https://pubmed.ncbi.nlm.nih.gov/37362028/
Other
• Bacterial sepsis triggers an antiviral response that causes translation shutdown. https://pubmed.ncbi.nlm.nih.gov/30507610/ • Incorporating Biobank Consent into a Healthcare Setting: Challenges for Patient Understanding. https://pubmed.ncbi.nlm.nih.gov/33275086/ • Collecting Biospecimens and Obtaining Biobank Consent From Patients in an Academic Health Care Setting: Practical and Ethical Considerations. https://pubmed.ncbi.nlm.nih.gov/34524131/ • Banking the Future: Adolescent Capacity to Consent to Biobank Research. https://www.jahonline.org/article/S1054-139X(15)00446-2/fulltext • The Access Technology Program of the Indiana Clinical Translational Sciences Institute (CTSI): A model to facilitate access to cutting-edge technologies across a state. https://pmc.ncbi.nlm.nih.gov/articles/PMC8057440/ • Comprehensive genetic testing for female and male infertility using next-generation sequencing. https://pubmed.ncbi.nlm.nih.gov/29779145/ • Sex discrepancy in the reduction of mucosal-associated invariant T cells caused by obesity. https://pubmed.ncbi.nlm.nih.gov/33332759/